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In healthy subjects, postprandial levels of GLP-1 rise, whereas patients with T2D or impaired glucose tolerance (IGT) exhibit reduced levels of meal-stimulated circulating GLP-1

Severe symptom prevalence varies based on the medication dosage Some patients with type 2 diabetes reported developing gastroparesis after using tirzepatide as part of their diabetes management plan Its important to monitor for gastrointestinal symptoms in patients using tirzepatide, especially if theres an existing risk for digestive issues

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